The risk of developing cloudy lenses in the eyes may be
linked to the use of cholesterol-lowering drugs known as statins, according to
a new study.
While the researchers can't prove the drugs caused the eye
condition, they found that people who took statins - such as Zocor and Lipitor
- were about 27 percent more likely to develop cataracts, compared to people
who didn't take the medication.
"The results were consistent that there was a higher
risk of being diagnosed with cataracts among statin users," Dr. Ishak
Mansi, the study's senior author from UT Southwestern Medical Center and the
Dallas VA Medical Center in Texas, said.
Statins are popular drugs that block a substance the body
needs to make cholesterol, which can get trapped in arteries and ultimately
lead to heart attacks and strokes.
About one-quarter of U.S. adults aged 45 and older take
statins. The drugs are especially recommended for people with diabetes or a
history of cardiovascular problems.
Researchers have looked at the link between statins and
cataracts before with mixed results. While some studies found that taking
statins lowered the risk of developing cataracts, other studies found the drugs
increased the risk.
For the new research, Mansi and his colleagues used data
collected from the medical records of people between the ages of 30 and 85
years old who were enrolled in one healthcare system in San Antonio, Texas, and
received care between 2003 and 2005.
In one analysis, they compared about 7,000 people who were
on statins for at least 90 days to about 7,000 people who were not on statins
but were similar in about 40 other characteristics, including other health conditions, medications
and healthcare use.
About 36 percent of statin users were diagnosed with
cataracts, compared to about 34 percent of people not taking statins.
In a second analysis, the researchers looked at people with
no other known health
conditions. It included 6,113 statin users and 27,400 people who did not take
statins.
After adjusting the results for the participants' age, sex,
weight, medications, healthcare use, other vision conditions and cigarette,
alcohol and drug use, the researchers found about 34 percent of statin users
were diagnosed with cataracts, compared to about 10 percent of people not
taking statins.
What's more, the researchers found that the risk of
developing cataracts increased with the length of time a person took the
medication.
While Mansi and his colleagues can't say how statins may
affect the formation of cataracts, they write in JAMA Ophthalmology that there
are a few possible explanations.
One is that the body needs high levels of cholesterol to
maintain a clear lens and statins may interfere with the cells that control
that process.
Dr. Jack Cioffi, head of ophthalmology at Columbia
University Medical Center in
New York, said the study is very well done, but has some limitations, including
that the researchers used billing data rather than medical records, so they
can't say how severe the cataracts were.
"I don't think we should overstate the significance of
this. It goes back to if there is a good reason for you to be on that statin,
it outweighs the risk of a mild increase in risk of cataract," Cioffi, who
was not involved in the new study, said.
He added that the treatments for cataracts have evolved over
time. The National Institutes of Health says the procedures to remove cataracts
are some of the most common and safest surgeries performed in the U.S.
"For patients themselves, my advice is to discuss what
your benefit and risk ratio is for you with your doctor," said Mansi, who
added that he hopes the results will also encourage people to improve their
cholesterol levels through lifestyle changes.
"This should motivate patients to do their part. Quit
smoking, eat healthy and be active so doctors don't have to give you a tablet
that may have some side effects," he said.
Source;
No comments:
Post a Comment