Diabetes and High Blood Pressure in Middle Age May Lead to Brain Cell Loss Later in Life

People who develop diabetes and high blood pressure in middle age are more likely to have brain cell loss and other damage to the brain, as well as problems with memory and thinking skills, than people who never have diabetes or high blood pressure or who develop it in old age.

This is according to a new study published in the March 19, 2014, online issue of Neurology. Middle age was defined as age 40 to 64 and old age as age 65 and older.

"Potentially, if we can prevent or control diabetes and high blood pressure in middle age, we can prevent or delay the brain damage that occurs decades later and leads to memory and thinking problems and dementia," says study author and Mayo Clinic epidemiologist Rosebud Roberts M.B., Ch.B.

For the study, the thinking and memory skills of 1,437 people with an average age of 80 were evaluated. The participants had either no thinking or memory problems or mild memory and thinking problems called mild cognitive impairment. They then had brain scans to look for markers of brain damage that can be a precursor to dementia. Participants' medical records were reviewed to determine whether they had been diagnosed with diabetes or high blood pressure in middle age or later.

For diabetes, 72 people developed it in middle age, 142 in old age and 1,192 did not have diabetes. For high blood pressure, 449 people developed it in middle age, 448 in old age and 369 did not have it.

Compared to people who did not have diabetes, people who developed diabetes in middle age had a total brain volume average of 2.9 percent smaller. In the hippocampus area of the brain, the volume was 4 percent smaller. They also were twice as likely to have thinking and memory problems.

Compared to people who did not have high blood pressure, people who developed high blood pressure in middle age were twice as likely to have areas of brain damage.

 "People who developed diabetes even in old age also were more likely to have areas of brain damage. Conversely, there were not many effects from high blood pressure that developed in old age," Roberts says. "Overall, our findings suggest that the effects of these diseases on the brain take decades to develop and show up as brain damage and lead to symptoms that affect their memory and other thinking skills. In particular, diabetes has adverse effects regardless of the age at which diabetes develops."

The study was supported by the National Institute on Aging, Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program, Rochester Epidemiology Project, National Institutes of Health, Robert Wood Johnson Foundation and European Union Regional Development Fund.

Source : www.medindia.net

Lady Finger An Easy Cure For Diabetes

Many people within the world square measure littered with polygenic disease. Here is a straightforward cure for polygenic disease. woman finger a natural vegetable which may be used as a cure for polygenic disease. rather than painful and overpriced treatment out there within the market

Lady Finger a straightforward Cure For polygenic disease
How To management polygenic disease From woman Finger?
Here is that the straightforward tip to regulate polygenic disease from woman finger. Take 2 or 3 woman fingers. Cut them from the centre and place them into the glass full with the water. Leave them for the complete night. within the morning take away woman finger and drink the water before breakfast. continuance identical method a day can assist you to cut back your sugar level. this easy tips is best than several alternative painful treatments. recent woman finger is best than broiled one.

How Raw woman Finger will facilitate in natural action Diabetes?

Low G.I Food:
the word G.I stands for Glycemic index. The one that is littered with polygenic disease ought to take diet enriched in Glycemic index. or so twenty G.I is gift in okra. that's terribly low. Diabetic patients will simply use Okra recipes as their meal to fill their abdomen and conjointly management their diabetic level.

Fight urinary organ Diseases:
lady finger is additionally sensible to stop your body from totally different urinary organ diseases. it's thought-about that prime sugar level impact your each kidneys badly. therefore by taking okra daily can stop your kidneys. Have Associate in Nursing moderate quantity of okra daily if you're a diabetic person.

Soluble Fibers:
Soluble fibers square measure vital to stay your kidneys healthy. They play their role in digestion of carbohydrates. woman finger is enriched with soluble fibers. some time down the digestion method and thus lower the sugar level in blood. These square measure a number of the most reasons for you to pick woman finger as a diet to regulate polygenic disease.

Source: Bestmedicalfacts

Women were less risk factors than men; for heart disease, why?

Women tend to develop heart disease about 10 years later than men, and new research suggests this is partly due to women's bodies being better at compensating for insensitivity to insulin, which controls blood sugar.

The study found that among people with insensitivity to insulin, women were less likely than men to have risk factors for heart disease and diabetes, such as high blood pressure and triglycerides. This, in turn, could delay the onset of heart disease, the researchers said.

The findings were published today (Sept. 24) in the Journal of Clinical Endocrinology and Metabolism.

Blood sugar

After eating carbohydrates, blood sugar rises. The pancreas produces insulin, a hormone that tells the body's cells to take up glucose from the bloodstream, thereby lowering blood sugar back to normal.

But some people's bodies are insulin-resistant, meaning their cells require a much higher amount of insulin to take up glucose from the blood.

When people develop insulin resistance, initially their blood sugar levels may remain normal, but over time, their bodies can no longer produce enough insulin to keep blood sugar levels in a healthy range.

At this point, people may develop metabolic syndrome, a group of five risk factors including high blood sugar, triglycerides and blood pressure, low levels of good cholesterol and a large waist. Metabolic syndrome can be a precursor to diabetes and heart disease.

Protective effect

Dr. Sun Kim, an endocrinologist at Stanford University Medical School, and her colleagues wanted to understand the factors that affected this process. They asked 468 women and 354 men to fast overnight.

Afterward, they injected the participants with glucose, insulin and a hormone that prevents the body from producing its own insulin, and then measured the participants' blood sugar a few hours later. The test allowed them to measure the exact relationship between insulin levels and blood sugar.

Women under 50 with insulin resistance, meaning they had high blood sugar after a meal, somehow avoided the risk factors associated with metabolic syndrome and heart disease. But as women aged, that advantage disappeared, and older women who were insulin-resistant had the same heart disease risk factors as men.

"Younger women, when they are resistant, are able to handle the complications a lot better," Kim said.

Still, it's not clear why younger women have some protection against heart disease. One possibility is that the hormones that affect the menstrual cycle play a role.

But the role of female hormones isn't clear-cut: For instance, giving women synthetic versions of hormones such as estrogen doesn't have the effects seen in the study, Kim said.

Either way, there are things that insulin-resistant people can do to avoid the onset of Type 2 diabetes and heart disease.

"The two lifestyle things that are closely associated with insulin resistance are gaining weight, and being sedentary," Kim told. Exercising and losing weight are the best ways to reverse insulin resistance, she said.

Source;

http://newsletter.dole.com/2013/why-heart-disease-strikes-women-later-than-men/?lang=en